In the face of the alarming number of opioid-related deaths in the U.S., there have been national efforts to increase emergency clinician prescribing of buprenorphine, a medication used to treat ...

Glucagon-like peptide receptor agonists (GLP-1RAs) like Novo Nordisk’s semaglutide (Ozempic, Wegovy) and Eli Lilly’s ...

Opioids are integral to analgesic protocols due to their high potency and efficacy in treating different pain in human and veterinary medicine. Injectable µ-receptor opioid agonists such as morphine, ...

1995; Yasuda et al. 1988). Instead, both OPC-14597 and OPC-4392 exhibit clear antagonist actions at postsynaptic receptors, as evidenced by inhibition of apomorphine-induced stereotypy and ...

They discussed naloxone (Narcan) saving lives by reversing opioid overdoses. They advocated expanding access to medication-assisted treatment (methadone, buprenorphine) to treat opioid addiction ...

Having shown last week that its opioid alternative can reduce post-surgery pain, Tris Pharma is back with another slice of clinical data to show that the drug is less likely to be abused.

A study showed that changes in the functioning of opioid neurotransmitters in the brain may underlie anorexia. A study conducted at Turku PET Centre in Finland showed that changes in the ...

2023), which works by binding to mu opioid receptors (known as MORs) in the brain and abruptly disrupting their signaling. However, those treated with naloxone often report that being rescued from an ...

Mu-opioid receptor (MOR) functions as a part of complex opioid system and supports both homeostatic and hedonic control of eating behavior. All subjects underwent a screening visit consisting of ...

So the way it works, and I'll try not to be too technical about this, is that we all have what's known as opioid receptors in our brains. The way that naloxone works is that it basically kicks off ...

From 2011 to 2021, prescription opioid use dropped by about 50% across the United States as a likely sign of attempts to reduce overuse of the drugs, previous studies found.