Reversing opioid overdoses in rats using a drug that does not enter the brain prevents the sudden and severe withdrawal symptoms associated with therapeutics that target the central nervous system.

New research suggests that δ-receptor agonists regulate intestinal motility and relieve abdominal pain in a mouse model of irritable bowel syndrome, potentially offering a novel CNS-targeted ...

One of the reasons for this dramatic, full-body response is that naloxone binds to opioid receptors all over the body, triggering involvement from organs like the skin and intestines, and not just ...

"This medication — which is a drug that inhibits sodium channels — works outside the brain on pain receptors," she noted. "To have a non-opioid option to prescribe in these cases is exciting ...

The company tested cebranopadol, a dual nociceptin/orphanin FQ peptide (NOP) receptor and µ-opioid peptide (MOP) receptor agonist, in a late-stage trial on patients who have undergone cosmetic ...

Opioids reduce pain by binding to receptors in the brain that receive nerve signals from different parts of the body. Those chemical interactions also give rise to opioids' addictive effects.

University of Mississippi researchers have discovered how a compound found in cannabis might be used to mitigate the negative effects of THC, a psychoactive compound in the plant. This ...

For the first time in two decades, the Food and Drug Administration (FDA) has approved a new class of medication that provides an alternative to addictive opioids for patients looking to manage ...

Attempting to reduce fatal opioid overdoses and encourage more people to seek treatment, fire department paramedics in Kitsap County will start administering the medication buprenorphine in the ...

The U.S. Justice Department on Friday accused pharmacy chain operator Walgreens Boots Alliance of contributing to the U.S. opioid epidemic by filling millions of unlawful prescriptions for ...