An A118G nucleotide exchange in exon 1 of the mu-opioid receptor causes an Asn40Asp substitution polymorphism in the receptor's extracellular domain. In vitro studies show that the Asp40 variant ...

The direct comparison of mice lacking each of the three opioid-receptor genes reveals that mu- and delta-opioid receptors act oppositely in regulating emotional reactivity. This highlights a novel ...

3 Wang et al. found that GPR139, a poorly understood GPCR, 4 interacts with the mu opioid receptor and acts as a brake to oppose the effects of opioid drugs. Blocking GPR139 would therefore be ...

New findings show that heavy drinkers with the G allele of the A118G polymorphism of the mu-opioid receptor gene have greater cravings after alcohol exposure than heavy drinkers homozygous for the ...

They’re the only opioid receptor that doesn’t cause respiratory depression. They can also have an anti-reward, dysphoric effect, which is the opposite effect of mu receptors. So, while they do ...

Those attempts were doomed to failure because all opioid drugs interact with the brain in the same way. They dock to a specific neural receptor, the mu-opioid receptor, which controls the effects ...

Naloxone is a competitive antagonist at the mu-opioid receptor. It is thought to reduce the intensity of itching through antagonism of the mu-opioid receptor both centrally and peripherally ...

Since levels of mu, delta, and kappa opiate receptors -- the three main types of opioid receptor in the brain and spinal cord -- are not thought to differ dramatically in men and women ...

Professor Anne Roivainen from the Turku PET Centre tells that this is the first time mu-opioid receptor levels have been assessed in peripheral regions using positron emission tomography (PET ...

Previous research showed that mice lacking the mu opioid receptor do not drink alcohol. A new study shows that mice lacking the delta opioid receptor drink more alcohol. The delta opioid receptor ...

Your body has three primary opioid receptor types: mu, delta, and kappa. These receptors are found on the surface of cells in the central and peripheral nervous systems. They respond to your body ...