The unfolded protein response (UPR) is a crucial signaling network that preserves endoplasmic reticulum (ER) homeostasis, impacting both health and disease. When ER stress occurs, often due to an ...

Scientists have developed a method for analysing the structure ... This cryogenic molecular surface and interfacial analysis advance makes this exciting possibility real. We expect to apply this new ...

This cryogenic molecular surface and interfacial analysis advance makes this exciting possibility real. "We expect to apply this new method to many systems, including lipid nanoparticles ...

Scientists have developed a method for analysing the structure ... This cryogenic molecular surface and interfacial analysis advance makes this exciting possibility real. We expect to apply this new ...

Scientists have developed a method for analysing the structure of lipid nanoparticles that could ... This cryogenic molecular surface and interfacial analysis advance makes this exciting ...

We identified known interactors of aSyn monomer and amyloid fibrils ... The detection of structure-specific interactors of disease-associated protein structural states should provide novel molecular ...

score of 0.849 on the CASP15 protein monomer structure prediction set, surpassing the performance of the ESM3-98B model, which scored 0.801. These results place Chai-1 at the cutting edge of molecular ...

Aquaporin-0 (AQP0) tetramers form square arrays in lens membranes through a yet unknown mechanism, but lens membranes are enriched in sphingomyelin and cholesterol. Here, we determined electron ...

This shows that the engineering of efficient lipid nanocarriers requires a delicate balance of interactions between all components of the nanocarrier on the molecular level. To study the impact of the ...