Exchangeable apolipoproteins can convert between lipid-free and lipid-associated states. The C-terminal domain of human apolipoprotein A-I (apoA-I) plays a role in both lipid binding and self ...

Journal Reference: Verschueren & Verstraete et al. Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 2019 DOI: 10.1038/s41586-019-1095-5 ...

Aerolysin is the founding member of a superfamily of β-pore–forming toxins whose pore structure is unknown. We have combined X-ray crystallography, cryo-EM, molecular dynamics and computational ...

Polymers are extensively used throughout industry, whether as naturally occurring materials like starch and cellulose, or synthetic commodities like nylon, polystyrene and polyethylene. Polymer ...

The molecular architecture of LPD-3 and putative lipid-transfer features. Credit: Nature (2025). DOI: 10.1038/s41586-025-08918-y Cryo-EM density map of the full-length LPD-3 complex.

Neo-1 is the first model to unify de novo molecular generation and atomic-level structure prediction in a single model, by generating latent representations of whole molecules instead of ...

More information: Anna M. Kotowska et al, Study on molecular orientation and stratification in RNA-lipid nanoparticles by cryogenic orbitrap secondary ion mass spectrometry, Communications ...

Lipid nanoparticles (LNP’s) came to prominence for delivery of RNA with the success of the Moderna and Pfizer BioNTech COVID-19 vaccines. They are also used to deliver therapeutic treatments including ...

28 Aug 2020 For the first time, researchers have solved the molecular structure of LRRK2, a major risk factor for Parkinson’s and autoimmune diseases. Structural biologists at the University of ...

Scientists at the University of California, Santa Barbara have created a new molecule that holds promise in fighting disease via gene therapy. Inherited diseases, as well as many cancers and ...