The cell cycle is regulated by cyclins, ... Finally, M cyclins increase in mitosis and fall once the cell has passed the spindle formation checkpoint.

Prolonged delays in mitosis and G2 DNA-damage stress both lead to cell-cycle arrest in G1. This work shows how these pathways normally lead to G1 arrest by different routes, and how cancer-associated ...

Prolonged delays in mitosis and G2 DNA-damage stress cause G1 cell-cycle arrest via different routes distinctly affected by cancer mutations. ... Sluder G, and Holland AJ A USP28-53BP1-p53-p21 ...

ConspectusCells are highly advanced microreactors that form the basis of all life. Their fascinating complexity has inspired scientists to create analogs from synthetic and natural components using a ...

Late-stage malignant melanoma is a cancer that is refractory to current chemotherapeutic treatments. The average survival time for patients with such a diagnosis is 6 months. In general, the vast ...