Prolonged delays in mitosis and G2 DNA-damage stress both lead to cell-cycle arrest in G1. This work shows how these pathways normally lead to G1 arrest by different routes, and how cancer-associated ...

Prolonged delays in mitosis and G2 DNA-damage stress cause G1 cell-cycle arrest via different routes distinctly affected by cancer mutations. ... Sluder G, and Holland AJ A USP28-53BP1-p53-p21 ...