Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...

mitochondrial membrane potential loss, and permeability transition pore activation, which can culminate in cell death. A review by a team of researchers at the Chinese Academy of Science ...

mitochondrial membrane potential loss, and permeability transition pore activation, which can culminate in cell death. A review by a team of researchers at the Chinese Academy of Science ...

For example, the team observed a higher mitochondrial membrane potential in peritoneal macrophages in the morning than later in the day. When the increased electrical voltage across the membrane ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

They found that the formation of SC-XL increases the number of folds in the inner mitochondrial membrane ... scientific knowledge but also highlights potential therapeutic strategies to ...

mitochondrial membrane potential loss, and permeability transition pore activation, which can culminate in cell death. A review by a team of researchers at the Chinese Academy of Science ...

These membrane contacts regulate ... biology Rebecca Lamason noted that these potential interactions are particularly interesting because bacteria and mitochondria are thought to have evolved ...

The FDA has extended the review period for the New Drug Application for elamipretide for the treatment of Barth syndrome.