Alternatively, the DNA polymerase can insert multiple bases, leading to the displacement of a small oligonucleotide, which is subsequently removed by a flap endonuclease. Mismatch repair primarily ...

However, the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in Huntington's disease remained unknown. The new study from UCLA Health and Jane and Terry ...

Advancing genome editing through studying DNA repair mechanisms Date: February 9, 2022 Source: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences ...

However, the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in Huntington’s disease remain unknown. The new study from UCLA Health and the Jane and ...

The process involves the recognition of damage which is then cleaved on both sides by endonucleases before resynthesis by DNA polymerase. The third excision mechanism is called mismatch repair and ...

Their work details how cells repair damaged DNA and preserve genes ... finding that they use mismatch repair to sharply reduce the frequency of errors. In making these discoveries, the researchers ...

Pembrolizumab (Keytruda), an anti-PD-1 antibody, cleared minimal residual disease and protected against recurrence in patients with DNA mismatch repair-deficient (dMMR) early-stage solid cancers ...

A new study uncovers how working at 35,000 feet may disrupt DNA repair and immune function in flight attendants, offering fresh insights into the health risks faced by cabin crews and the urgent ...