We introduce MADna, a sequence-dependent coarse-grained model of double-stranded DNA (dsDNA), where each nucleotide is described by three beads localized at the sugar, at the base moiety, and at the ...

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

Following 6 weeks of pembrolizumab, dosed once every 3 weeks, patients were assessed with radiographic imaging. Circulating tumor DNA (ctDNA) was assessed before and after 3 weeks of treatment.

Summary: Microsatellite instability (MSI) and deficient DNA mismatch repair (dMMR) drive genomic instability in several aggressive tumor types. Cancers exhibiting MSI-H or dMMR phenotypes accumulate ...

A new study uncovers how working at 35,000 feet may disrupt DNA repair and immune function in flight attendants, offering fresh insights into the health risks faced by cabin crews and the urgent ...

CMMRD is caused by bi-allelic germline mutations in mismatch repair (MMR) genes, which normally help maintain DNA stability. Researchers analysed 41 tumours from 17 individuals with CMMRD to ...

Researchers at the Centre for Genomic Regulation (CRG) created an AI tool which dreams up DNA regulatory sequences not seen before in nature. The model can be told to create synthetic fragments of ...

DNA damage repair (DDR) is a fundamental aspect of cellular biology that protects against genomic instability and diseases, such as cancer. Numerous proteins are involved, either directly or ...

Two proteins, TRF2 and RAP1, work together to block a repair process that would otherwise treat the natural ends of chromosomes as broken DNA and try to fix them. Formation of the TRF2–RAP1 ...