Inherited retinal degenerations (IRDs) are a group of genetic disorders that lead to progressive vision loss as the light-sensing cells of the eye-the photoreceptors-die due to mutations in genes ...

Following a 14-day oral dosing regimen, Telomir-1 reversed central vision response and vision acuity, restored retinal degeneration and architecture, and significantly reduced oxidative stress ...

The findings in animals may help advance treatment options for dry age-related macular degeneration (AMD), which ... One graft consisted of retinal pigment epithelial (RPE) cells grown on a ...

Reference: Sudharsan R, Murgiano L, Ahuja A, et al. Novel photoreceptor-specific promoters for gene therapy in mid-to-late stage retinal degeneration. Mol Ther. doi: 10.1016/j.ymthe.2025.05.020 This ...

Scientists have developed new tools to improve gene therapy in advanced stages of inherited retinal diseases (IRDs) such as retinitis pigmentosa and Leber congenital amaurosis. Inherited retinal ...

More information: Rohan Gupta et al, iPSC-RPE patch restores photoreceptors and regenerates choriocapillaris in a pig retinal degeneration model, JCI Insight (2025). DOI: 10.1172/jci.insight.

Worldwide, 1 in 3,000 people suffer from IRDs, which cause progressive vision loss and retinal degeneration. So far, 326 of the roughly 20,000 human genes have been linked to these disorders.

Stargardt disease is a genetic eye disorder that causes retinal degeneration and vision loss. Stargardt disease is the most common form of inherited macular degeneration. The progressive vision ...