Here, we demonstrate a structure-based small molecule virtual screening and lead optimization pipeline using a homology model of a difficult-to-drug G-protein-coupled receptor (GPCR) target.

In recent years, large-scale structure-based virtual screening has attracted increasing levels of interest for identification of novel compounds corresponding to potential drug targets. It is critical ...

Abstract We investigated the effects of melatonin (MT) treatment on the physiological quality and cell wall metabolism of kiwifruit during a 12-day shelf life period (20 ± 1 °C, 90 ± 5% RH), after 90 ...

Article CAS PubMed Google Scholar McInnes, C. & Sykes, B.D. Growth factor receptors: structure, mechanism and drug discovery. Biopolymers 43, 339–366 (1997). Article CAS PubMed Google Scholar ...

Melatonin has been used successfully to treat insomnia, but has not received regulatory approval by the FDA because it can be sold freely as a food supplement. This has prompted a search by ...

“At around 4:40 a.m., the Vicksburg Fire Department was dispatched to 1411 Division St. in response to a reported structure fire,” VFD Chief Derrick Stamps said.

Williams, W.R. (2018) Cell Signal Transduction Hormones, Neurotransmitters and Therapeutic Drugs Relate to Purine Nucleotide Structure. Journal of Receptors and Signal Transduction, 38, 101-111.

Days after a deadly concrete landing collapsed, a GoFundMe is raising thousands to help support the family of the 15-year-old Portsmouth High School freshman.

Aaron Rodgers contract details Rodgers signed a one-year deal with the Steelers, which has a base value of $13.65 million, according to Spotrac. He received a $10 million signing bonus and will ...

COLUMBUS, Ohio — Ohio State’s athletic department is teaming up with Learfield to form the Buckeye Sports Group. The partnership will bring OSU’s NIL collectives in-house, a strategic move ...

When Steve Jobs returned to Apple, in 1997, it had a conventional structure for a company of its size and scope. It was divided into business units, each with its own P&L responsibilities ...