More information: Kenji Oishi et al, MHC Class II‐Expressing Mucosal Mast Cells Promote Intestinal Mast Cell Hyperplasia in a Mouse Model of Food Allergy, Allergy (2025). DOI: 10.1111/all.16477 ...

Mast cells are hematopoietic cells residing in barrier tissues, e.g., epithelia of the gastrointestinal (GI) tract, lungs, and skin, best known for their roles in IgE-mediated allergies, affecting ...

Mast cells and IgE promote immunity of avoidance. Model of mast-cell-mediated avoidance behavior in the framework of type 2 immunity. Barrier damage facilitates entry of antigens (for instance ...

image: Mucosal mast cells are immune cells that arise from bone marrow and play a key role in the sudden onset of food allergy symptoms view more Credit: Associate Professor Nobuhiro Nakano from ...

Mast cells are well known to persons suffering from allergies because they secrete messenger substances such as histamine, which cause annoying to health-threatening allergic symptoms.

The researchers found that in patients with IgG4-RD, serum levels of IgG4 increased to ≥1.4 g/L and IgE increased to ≥125 kIU/L in 81 and 54 percent, respectively, compared with 6 and 16 ...

The function of mast cells, which are part of the immune system, is still a mystery. Scientists at the German Cancer Research Center (DKFZ) have now shown in mice: mast cells function as a sensor ...

When someone becomes allergic, their mast cells capture and display antibodies, specifically immunoglobulin E (IgE), for that specific allergy-triggering substance – an allergen, almost always a ...

Mast cells as a sensor: Enigmatic immune cells help us avoid harmful allergens Date: July 12, 2023 Source: German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) Summary: The ...