If the cells become overreactive, releasing too many mediators at the wrong time, a person can end up flushed, dizzy, wheezy, or exhausted. This is called mast cell activation syndrome, or MCAS.

Food allergy, or the aggressive immune system reaction following the consumption of a certain food or food ingredient, typically involves immunoglobulin E (IgE) antibodies and can be potentially ...

During an allergic response, the allergen is captured by a preexisting complex of an IgE antibody bound to its high-affinity receptor FcRI on the membrane of mast cells and basophils.

Stress Mediators & Mast Cell Activation In the skin, mast cells are predominantly localized to the upper dermis and close to blood vessels, skin appendages and neurons (Figure 1).

Now, a new study by scientists from Juntendo University, Japan, reveals the role of major histocompatibility complex class II (MHCII)-expressing mucosal mast cells in IgE-mediated food allergy.

In the Hoxb8 mast cell activation test (Hoxb8 MAT), mast cells grown in the laboratory are brought into contact with blood serum from allergic patients.

Mast cell activation syndrome (MCAS) is a condition where the mast cells are inappropriately triggered.

BACKGROUND: IgE has been known for mediating endothelial cell dysfunction and mast cell (MC) activation to fuel asthma-aggravated high-fat diet–induced atherosclerosis. However, it remains unclear for ...

Doing so enabled these nanoparticles to inhibit the function of mast cells, a type of immune cell which are in charge of triggering allergic reactions. Using this two-step process, the allergen ...

Mast cells are well known to persons suffering from allergies because they secrete messenger substances such as histamine, which cause annoying to health-threatening allergic symptoms.