Severe allergic reactions involving a cytokine storm can follow vaccination for respiratory viruses such as influenza or COVID-19, writes Irene Mavrakakis, M.D., in the summer issue of the Journal of ...

Learn all about anaphylaxis, its symptoms, causes, and treatment. Recognise signs early and act quickly to manage this severe ...

Onyinye I. Iweala discusses a recently published review that provided updated recommendations for ordering tryptase tests, sharing her expert insights. State‑of‑the‑art recommendations for clinician ...

Diagnosing mast cell sarcoma is difficult ... reducing and killing off the number of mast cells and reducing elevated tryptase levels, and sometimes reversing organ damage.” ...

and demonstrating symptomatic improvement with medications targeting mast cell stabilization or mediator blockade. Laboratory testing may include serum tryptase, histamine, prostaglandin D2 ...

Briquilimab targets c-Kit to address mast cell diseases. Patients saw substantial reductions in tryptase as early as week 1. 100% of patients with a single 240 mg dose had complete response at week 8.

Pharmacodynamics: BLU-808 showed dose-dependent serum tryptase responses, reflecting evidence of mast cell target engagement across multiple dose levels. In the SAD cohorts, reductions in ...

Ultimately, her research led to mast cell activation syndrome ... Your blood shows a substantial spike in a chemical (typically tryptase) released by mast cells within four hours of a symptomatic ...

Interestingly, Imatinib which is a c-Kit inhibitor commercialized by Novartis (NVS) has demonstrated its efficacy at reducing mast cell count, tryptase release and airway hyper responsiveness in ...

She added, "mast cell activation, or mast cell hyperactivity ... preferably an increase in serum tryptase levels from the individual's baseline to plus 20% + 2 ng/mL. Response of symptoms to ...

Jasper saw fast, steep reductions in serum tryptase, a mast cell biomarker. However, tryptase levels were only stable for around four weeks. After that, levels of the biomarker began to rise and ...