A MUM suffering severe bloating died after she had a suspected allergic reaction to a CT scan. Yvonne Graham, 66, went into ...

Briquilimab targets c-Kit to address mast cell diseases. Patients saw substantial reductions in tryptase as early as week 1. 100% of patients with a single 240 mg dose had complete response at week 8.

Pharmacodynamics: BLU-808 showed dose-dependent serum tryptase responses, reflecting evidence of mast cell target engagement across multiple dose levels. In the SAD cohorts, reductions in ...

and a laser focus on redefining treatments for mast cell-driven diseases. The Phase 1 trial for BLU-808 is already turning heads, showing over 80% reductions in serum tryptase levels. In her own ...

Mast cell mediators, histamine, tryptase and NGF, released upon activation can excite sensory nerves and promote their growth. Corticotropin-releasing hormone, sensory nerves and the number of ...

BPMC stock rallies 18% on the company's optimistic 2025 outlook encompassing Ayvakit sales growth and pipeline progress.

Results from a skin biopsy confirmed a buildup of abnormal mast cells, a type of immune cell, and another test showed high levels of serum tryptase (a substance released by mast cells).