SAN DIEGO and NEW YORK, May 7, 2025 /PRNewswire/ -- Aspen Neuroscience has released 6-month data from the first three patients dosed in the ASPIRO Phase 1/2a trial of ANPD001, an investigational ...

Splenomegaly, hematologic changes, and elevated mast cell protease 1 levels were detected in these mice as well. Declines in temperature following MRGPRX2-mediated anaphylaxis were significantly ...

interferon-gamma (IFNγ), mucosal mast cell protease (MMCP)-1, and various interleukins (IL) were measured to determine the safety profile of the oral immunotherapy. The researchers also tested ...

Table 1. Patient demographics ... end quantitative MC protease analysis. After the FISH of CPA3 mRNA in the Cy3/555 nm channel, slides were subjected to subsequent immunofluorescence ...

and the proangiogenic proteins neuropilin 1 (NRP1) and aminopeptidase N (ANPEP) were also both increased. Localization and Quantification of Denatured Collagen in Submacular Sections. Mast cell ...

Serum mouse mast cell protease 1 (MMCP1) level was used to measure extent of mast cell degranulation. Histamine receptor 1 (HR1) antagonists, β-adrenergic agonists, and a spleen tyrosine kinase (Syk) ...

Mast cell activation was quantified in serum using MC-derived proteases: β-tryptase (ELH-TPSB2-1, Ray Biotech), CPA3 (CPA3, LS-F7363, LS Bio) or chymase (50-149-8059, Biomatik). Mast cell tryptase ...

Introduction: Mouse mast cell protease-4 (mMCP4) is a chymase that has been implicated in cardiovascular diseases, including myocardial infarction (MI). Here we tested a direct role of mMCP4 in mouse ...

However, tissue IGF-1 levels increase only transiently because it is rapidly degraded by the chymase, mouse mast cell protease 4. Mouse mast cell protease 4 deletion promotes cardiac cell survival by ...

One possible mechanism involves activation of protease-activated receptors (PARs ... we found that MCGs upregulate the secretion and gene expression of MCP-1 and IL-8 in human ECs. Human mast cell ...