The randomized, double-blind, placebo controlled parallel group decentralized trial will enroll 60 patients with idiopathic Mast Cell Activation Syndrome (“MCAS”). Per the protocol ...

The randomized, double-blind, placebo controlled parallel group decentralized trial will enroll 60 patients with idiopathic Mast Cell Activation Syndrome (“MCAS”). Per the protocol, patients will ...

Part of the immune response, mast cells are a type of white blood cell that releases histamine in response to bacteria and allergens. In systemic mastocytosis, mast cells accumulate in the bone ...

They found that TLR4, which binds the gram-negative product lipopolysaccharide, and TLR2, which binds peptidoglycan (PGN) from gram-positive organisms (e.g. Staphylococcus aureus) induce distinct mast ...

Mast cell activation syndrome, a disorder involving immune cells gone awry, is increasingly recognized as the culprit behind many medical mysteries. The first key to understanding this complex ...

A representative subject demonstrating the pDC and B cell gating protocols along with quilizumab staining ... pDCs are present in much lower abundance compared to conventional DCs, mast cells, and ...

Ultimately, her research led to mast cell activation syndrome, or MCAS, a condition in which mast cells (a type of white blood cell) overreact for reasons that aren’t always clear. These ...

mast cell progenitors; Cycling = Cycling progenitors). The bar plot below shows the percentage of cells per cluster. (C) Dot plot showing the ADT expression within clusters. The color indicates mean ...

Depending on one's perspective, "mast cell activation syndrome (MCAS)" is either a relatively rare, narrowly defined severe allergic condition or a vastly under-recognized underlying cause of ...

This important study uses single-cell RNA-seq to obtain a more granular understanding of cell subsets within allergic contact dermatitis in a model system with DNFB. The convincing data revela unique ...

body organs and/or bone marrow), mast cell cancers (for example, mast cell leukemia, mast cell sarcoma) or even the benign tumor of mastocytoma. Secondary MCAS is when the mast cells are ...