Renal failure in multiple myeloma typically occurs when the kidneys fail to filter waste products from the blood, leading to ...

Abstract:        Obesity, a growing global issue, has been closely associated with an increased risk of various cancers, especially breast cancer. El ...

NF1 drug development accelerates with novel treatments aiming to surpass current MEK inhibitors in efficacy, safety, and patient-friendly delivery. The evolving NF1 landscape highlights how innovation ...

Key Laboratory of Application of Ecology and Environmental Protection in Plateau Wetland of Sichuan, Xichang University, Xichang 415000 Sichuan Province, China Key Laboratory of Animal Disease ...

The integrated stress response (ISR) serves as a critical adaptation mechanism ... with multiple metabolic perturbations induced by commonly used small-molecule inhibitors, we systematically studied ...

Despite the availability of treatments like selective serotonin reuptake inhibitors (which increase serotonin levels ... on the specific molecular pathways directly involved in the stress response.

were treated ex vivo with combination BRAF/MEK inhibitors dabrafenib and trametinib, and single-cell RNA sequencing (sc-RNAseq) was used to dissect the molecular features of response in differentiated ...

BRAF and CRAF potentially creating a more complete and durable anti-tumor response through maximal RAS/MAPK pathway inhibition. In contrast to currently available MEK-only inhibitors, avutometinib ...

is among the most cardiotoxic tyrosine kinase inhibitors and causes mitochondrial dysfunction. Whether ponatinib-induced mitochondrial dysfunction triggers the integrated stress response (ISR) to ...

Doing so helps to turn up your parasympathetic nervous system — the counterbalance to the “fight or flight” stress response — and lower your blood pressure and regulate your heart rate.