New research uncovers hidden rules of immune response, opening doors for better vaccines and immunotherapies
Scientists at the Institute for Systems Biology (ISB) have uncovered key insights into how T cells—the body's frontline ...
eLife13d
Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer
This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...
BMJ19d
SGLT2 inhibitors and dietary calorie restriction for type 2 diabetes remission
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The EMBO Journal20d
Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response
Dose-dependent phosphoproteome profiling of four ATR inhibitors following DNA damage induction by GEM revealed a strong block of the DNA damage response pathway, including phosphorylated pS468 of ...
PNAS26d
Ufmylation reconciles salt stress-induced unfolded protein responses via ER-phagy in Arabidopsis
their detailed roles in plant development and stress responses remain elusive. In this study, we identified Ufl1 as an ATG8 interactor in Arabidopsis and demonstrated that Ufl1 maintains ER ...
Medical Xpress27d
Early life stress alters brain metabolism differently in male and female mice, study reveals
Early life stress (ELS) can have long-lasting effects ... highlighting the need to understand how biological sex influences responses to trauma. A study published in Communications Biology has ...
Psychology Today28d
The Unexpected Upside of Stress: Pressure Builds Strength
Studies, such as those by Dr. Robert Sapolsky at Stanford University, highlight that when stressors feel beyond our control, they activate the body’s stress response more intensely and for ...
Frontiers29d
MiR-4298 and lncKRTAP5-6-3 regulated Cathepsin D expression through ERK-MAPK signaling pathway in chronic UVB-damaged HaCaT cells
cells and explored miR4298-MAPK/ERK signaling pathway-Cathepsin D-lncKRTAP5-6-3 mechanisms in photoaging cells. Methods: HaCaT cells were irradiated with 12 mJ/cm 2 UVB once a day for 7 days. miR-4298 ...