A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

Objectives In the complex panorama of autoimmune diseases, the characterisation of pivotal contributing autoantibodies that are involved in disease progression remains challenging. This study aimed to ...

A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function ... the H3K79 methyltransferase DOT1L has opposite effects on ...

In the late 19th century, Karl Weierstrass invented a fractal-like function that was decried as nothing less than a “deplorable evil.” In time, it would transform the foundations of mathematics.

The RNA methyltransferase activity of SPOUT1/CENP ... pathogenic SPOUT1 variants with reduced activity and compromised function in spindle organization. Accurate chromosome segregation into ...

National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States ...

This manuscript provides important structural insights into the recognition and degradation of the host tRNA methyltransferase TRMT1 by SARS-CoV-2 protease nsp5 (Mpro). The data provide compelling ...

Medically reviewed by Nicholas R. Metrus, MD Akinesia is the inability to perform certain physical movements due to problems ...

Concrètement, ce phénomène serait dû à un déséquilibre entre l’histamine et l’activité restreinte des enzymes de décomposition de l’histamine, la diamine oxydase (DAO) et l’histamine ...

The well-known function role of R-M systems is to protect the host ... sites and hydrolyzes DNA when the sequence is unmethylated, and a corresponding DNA methyltransferase, which methylates DNA on ...

Des travaux, publiés dans la revue Cancer Discovery, montrent un nouveau mécanisme de résistance aux agents alkylants dans les SCLC, impliquant la méthyltransférase SMYD3. Son inhibition resensibilise ...