scientists could only study autophagy by examining cells with electron microscopes. Using this tool, they established that after autophagosomes form, they fuse to the lysosomal membrane to form a ...

Accumulation of fat molecules is detrimental to the cell. Researchers from the Yong Loo Lin School of Medicine, National ...

The protein Spns1 helps transport fat molecules out of lysosomes, preventing harmful buildup and offering insights for rare ...

To combat this autophagy, the research team designed ... upon light activation, disrupted the lysosomal membrane and prevented its fusion with autophagosomes—structures responsible for isolating ...

The autophagosomes, autolysosomes and lysosomes can be considered as different stages of the cellular recycling process. Therefore, when cells notice they have too much "junk" inside, autophagy ...

New research has made a breakthrough in understanding how our cells manage to stay healthy by recycling important fat ...

Once fats are broken down in the lysosome, they serve several important roles in the cell. One is membrane repair and maintenance. The broken-down fat components, such as phospholipids and ...

By supplying membranes from donor sources, ATG9-mediated cycling systems, which comprise the core proteins ATG9, ATG2, VPS13D and WIPI1/2, facilitate the elongation of phagophore.

The autophagosomes, autolysosomes and lysosomes can be considered as different stages of the cellular recycling process. Therefore, when cells notice they have too much "junk" inside, autophagy ...

Autophagy, which literally means "self-eating," is a cellular cleaning-out process that maintains our bodies in good order, ...

In 2016, "Autophagy" (*1) (Fig. 1) became famous when Professor ... It was shown that Plaat1 translocates when the mitochondrial or lysosomal membrane is partially damaged. It was also shown that the ...

Breakthrough NUS discovery sheds light on cellular recycling mechanism and potential for treating rare diseases Singapore ...