Chymase from mast cells was present at high levels in the sera of these patients, further proof of mast cell activation in COVID-19. Thus, SARS-CoV-2 causes mast cell activation in vivo.

Mast cells are hematopoietic cells residing in barrier tissues, e.g., epithelia of the gastrointestinal (GI) tract, lungs, and skin, best known for their roles in IgE-mediated allergies, affecting ...

Mast cells and IgE promote immunity of avoidance. Model of mast-cell-mediated avoidance behavior in the framework of type 2 immunity. Barrier damage facilitates entry of antigens (for instance ...

More information: Kenji Oishi et al, MHC Class II‐Expressing Mucosal Mast Cells Promote Intestinal Mast Cell Hyperplasia in a Mouse Model of Food Allergy, Allergy (2025). DOI: 10.1111/all.16477 ...

Secondary MCAS is when the mast cells are inappropriately triggered/over-activated by certain IgE antibodies or by certain stressors (for example, certain drugs, physical activity, stress ...

“We thought the mice without mast cells would do better than the wild-type mice, because the infection wouldn’t be provoking mast cells to release histamine,” recalls Caughey. “In fact, they did much ...

Mast cells as a sensor: Enigmatic immune cells help us avoid harmful allergens Date: July 12, 2023 Source: German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) Summary: The ...