While Rosetta will be her first leading role, Lizzo is no stranger to the big or small screens. She made her big-screen acting debut in 2019's Hustlers, playing a flute-playing exotic dancer.

Credit: Left-Christopher Polk/Billboard via Getty Images; Right-Sister Rosetta Tharpe singing and playing a Gibson ... And while Lizzo is known to whip out her flute (which fans better know ...