The structure showed 12 transmembrane helices in two pseudo-symmetric bundles and two periplasmic subdomains. Experiments showed that the coiled-coil domain, whose predicted model extends from one of ...

The molecular structure of the MmpL4 efflux pump in Mycobacterium tuberculosis reveals a coiled-coil domain essential for exporting the siderophore mycobactin and for bedaquiline resistance.

Neo-1 is the first model to unify de novo molecular generation and atomic-level structure prediction in a single model, by generating latent representations of whole molecules instead of ...