Topline results were announced from a phase 3 trial evaluating valiltramiprosate (ALZ-801) in apolipoprotein ε4 allele (APOE4) carriers with early Alzheimer disease (AD). Valiltramiprosate is an ...

Furthermore, due to safety concerns and restrictions, these disease-modifying therapies are not optimal for APOE4/4 homozygotes, the most vulnerable Alzheimer’s patient population. At Alzheon we ...

But in the presence of the APOE4 protein-;the most important genetic risk factor for Alzheimer's disease-;the same cells cause harmful inflammation and clumps of misfolded proteins, according to a ...

But in the presence of the APOE4 protein - the most important genetic risk factor for Alzheimer's disease - the same cells cause harmful inflammation and clumps of misfolded proteins, according to ...

Opens in a new tab or window A working group of senior investigators, convened by the Alzheimer's Disease Sequencing Project (ADSP), has reached a consensus that the APOE4 gene, long debated in ...

That's what's at work with research into the APOE4 gene. According to a recent study released by the National Institutes of Health and published in "Nature Medicine," the disease may be more ...

What do the findings mean for your Alzheimer’s risk, and should you get tested for the APOE4 gene? Here are answers from neurologists Ayesha Sherzai, MD, and Dean Sherzai, MD, PhD, the co-direct ...

This means the APOE4 gene may no longer merely a risk factor but the driver behind a new stand-alone genetic Alzheimer's disease type that could impact up to 10 million Americans and more than 200 ...

There are variations in the sequence of this gene that create genetic variants of APOE, and one of those variants: APOE4, has long been known to increase a carrier's risk of Alzheimer's disease. Now, ...

APOE3 is thought to confer a neutral risk of the disease. APOE4, on the other hand, is bad news. It has long been recognized that people with at least one copy of the APOE4 gene have an elevated ...

Scientists have long known a gene called APOE4 is one of many things that can increase people’s risk for Alzheimer's, including simply getting older. The vast majority of Alzheimer’s cases ...