The entorhinal cortex (EC) stands out as a critical brain region affected in the early phases of Alzheimer’s disease (AD), with some of the disease’s pathological processes originating from this area, ...

AD can compromise brain function and lead to severe neurological abnormalities associated with dementia. The human Apolipoprotein E (ApoE4) gene is a strong risk factor for AD. However, comprehensive ...

This observational study from the UK Biobank provides an important investigation into the associations between menopausal hormone therapy and brain health in a large, population-based cohort of ...

pCenter for Innovative Care in Aging, Johns Hopkins University, Baltimore, MA, USA qDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MA, USA rDepartment of ...

But there are different versions of this gene. One version, called apoE4, is linked to a much higher risk of developing Alzheimer’s disease. In fact, more than half of the people with Alzheimer ...

Copyright: © 2024 The Author(s). Published by Elsevier Ltd. Accordingly, young adulthood can be viewed as a window of opportunity for early intervention, which could ...

Human APOE isoforms in astrocytes: Expression in astrocytes alone induced formation of fibrillar amyloid plaques (APOE4 > APOE2 > APOE3) and reduced soluble Aβ aggregates (APOE2 > APOE4 ≈ APOE3).

even outside the U.S. His long-term goal is to create a brain health risk assessment that pairs 5ADCSI with genetic testing for APOE4, the gene variant linked to Alzheimer's disease, to help people ...

The FDA recommends on Leqembi's label that doctors conduct testing for a gene called APOE4 that is associated with a higher risk of Alzheimer's as well as brain swelling associated with ...

Nuala and Gerry Paley first met when she was 21 and he was 23. Their relationship didn’t take off properly in the beginning, but they met again eight years later and were married within six months.