Some people are now using low-dose oral ketamine to manage treatment-resistant depression and post-traumatic stress disorder (Journal of Psychopharmacology, June 5, 2025). The FDA has not approved oral ketamine for any indication.

A related compound, esketamine, has been approved in the European Union and the United States for the emergency treatment of treatment-resistant depression, administered as a nasal spray under strict medical supervision.

Elon Musk isn’t new to controversy, but this time the firestorm came in the form of a drug test. After weeks of speculation following a New York Times report accusing him of heavy ketamine and drug use during his time in the Trump administration as head of the Department of Government Efficiency (DOGE),