Isaac Guerendo is currently listed as RB2 on the San Francisco 49ers depth chart. It will be the second season for the ...

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Nick Skrip runs through the 10 best running back handcuffs to target in your upcoming 2025 Fantasy Football drafts.

After an unexpectedly awful 6-11 season in 2024, the 49ers endured a painful cost-cutting offseason in which they parted with ...

With the addition of rookie Jarquez Hunter, do the Los Angeles Rams now have the best group of running backs in the NFC South ...

Brock Purdy is no longer the best bargain in football. That means the 49ers have to push all the right buttons to build a ...

McCaffrey might be 29 years old and coming off a horrible injury-plagued year, but that will not keep some Fantasy managers from taking him with a top-15 overall pick (if not in the top 10). It's ...

Maybe you're fading McCaffrey and are targeting Guerendo instead. Or maybe it's the middle-to-late rounds and you want a talented running back who's one injury away from a lot of touches. Guerendo ...

Star running backs Christian McCaffrey and Saquon Barkley won NFL Offensive Player of the Year in consecutive years, though ...

Here are the top 10 rushing duos heading into the 2025 season, according to FOX Sports Research.

Isaac Guerendo will be ready to go when his San Francisco 49ers begin the 2025 season versus the Seattle Seahawks, on Sept. 7 at 4:05 p.m. ET. Last year Guerendo racked up 420 rushing yards (26.3 ...