Thrombin, in turn, facilitates the activation of the intrinsic pathway, causing an increase in thrombin generation in an amplification loop. [ 28 , 30 , 31 ] The presence of platelets increases ...

APTT is commonly used for the evaluation of the intrinsic pathway of blood coagulation in the clinic. Our results demonstrated that the APTTs were 25.16±4.03 s (ZSS1 group), 28.51±2.47 s (ZSS2 ...

New regulator of the blood coagulation cascade discovered Date: November 15, 2012 Source: George Washington University Summary: Medical researchers have discovered a new regulator of the blood ...

Another aims at microparticles, cell fragments that seem to promote coagulation ( pages 1015–1019 and 1020–1025 ). Nature Medicine - Two new therapeutic strategies show promise in mouse models ...

Tissue-factor expression directly activates the extrinsic coagulation pathway and, via feedback loops, indirectly activates the intrinsic pathway.

Whilst several anticoagulants currently exist, they have limited discrimination between the intrinsic pathway (responsible for thrombosis) and extrinsic pathway (responsible for hemostasis), both ...

For Coagulation, challenges both outside and inside the laboratory’s control can mean the difference between accurate and potentially inaccurate results. In this webinar, you will learn about patient ...

Coagulation disorders are usually due to a genetic mutation and are often treatable with medications. They can cause excessive bleeding if the body is unable to form blood clots properly.

If blood does not clot, life-threatening bleeding can occcur. Find out about how blood clots, how clotting factors work, and how treatment has improved the outlook for people with hemophilia.

Asthma is characterized by chronic inflammation of the airways, contraction of smooth muscle, overproduction of mucus, and remodeling of the airway wall. In many forms of asthma, there is an ...