Insulin resistance is a hallmark of multiple metabolic disorders, including type 2 diabetes, obesity, metabolic syndrome, and polycystic ovary syndrome. It ...

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study by a team at the Max Planck ...

Type 2 diabetes (T2D) is a global metabolic epidemic driven by insulin resistance (IR), chronic inflammation, and β-cell ...

This bioinformatics-assisted review describes key biological elements of known pathways, such as the forkhead box protein O1/leptin receptor and Janus kinase/signal transducer and activator of ...

Insulin normally tells the body to absorb glucose (sugar) from the bloodstream via a complex and dynamic signaling pathway.

In the liver, the insulin-signaling cascade branches downstream of its receptor to form one pathway that suppresses gluconeogenesis and another pathway that activates de novo lipogenesis (Figure 3).

By suppressing this pathway, turmeric reduces inflammatory mediators that interfere with insulin signaling, essentially removing obstacles to normal glucose metabolism rather than forcing greater ...

Inceptor’s role in blocking the insulin receptor and reducing the cells’ insulin sensitivity and weakening the signaling pathway was described in the 2021 Nature paper, “ Inceptor ...

Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors. Science Advances, 2023; 9 (31) DOI: 10.1126/sciadv.adg0666 ...