IRF1 was also found to be associated with the impairment of the insulin/IGF signaling pathway. Previous studies have linked the expression of IRF1 with male sex, older age, diabetes, and COVID-19.

Hu and colleagues showed a protein controlling the PI3K/Akt pathway, a pathway targeted by more than 40 anti-tumor drugs, is absolutely required for the synthesis, processing and secretion of insulin.

Journal Reference: Semple et al. Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis. Journal of Clinical Investigation, Jan 29, 2009; DOI: 10.1172/JCI37432 ...

In conclusion, we have shown that insulin signaling and EPC survival are impaired in Zucker fatty insulin-resistant rats. This defect can be ameliorated significantly by a knockdown of RelA ...

Insulin moves glucose -- sugar -- from the bloodstream into the body's cells where it can be used. The researchers suppressed one of the key proteins in this pathway in honeybee larvae.

The authors propose that part of the insulin signaling pathway (the branch that activates the protein kinase AKT is inhibited in the fat body of gamergates and that this may be mediated by a ...

The insulin signaling pathway is very well known for its function to control blood sugar levels, and its mis-regulation is a key characteristic of diabetes. And while its role in cellular wound repair ...

After the striatum is exposed to amphetamines, insulin signaling regulates dopamine via downstream phosphotidylinositol 3-kinase and protein kinase B targets. This in vivo evidence points toward a ...

Researchers have produced a comprehensive picture of insulin signaling in mice and suggest that it is shaped by entangled effects of genetics and diet. The research, published today as a Reviewed ...

As such, our results present a previously uncharacterized insulin-signaling pathway involving Rab5, the motor protein dynein, and the cytoskeleton to regulate directional GLUT4 movement, facilitating ...

Original Article Published: 25 March 2009 Clozapine Interaction with Phosphatidyl Inositol 3-Kinase (PI3K)/Insulin-Signaling Pathway in Caenorhabditis elegans Rakesh Karmacharya, Gregory R ...