Most organic drugs contain one acid group, usually a carboxylic ... and organic nondrug ions that comprise drug acid-base conjugate pairs and salts. [3,12,13,14,22,23,24,25,27,28,29,43,50 ...

Furthermore, our findings may pave the way for future drug design by identifying druggable conformations ... index for the contact between the amino acids i,j was defined as a Z-score of the energy of ...

to acetic acid (CH 3 COOH) using a nano-heterostructure catalyst. This catalyst features Rh-Zn atomic-pair dual sites confined within a MoS 2 lattice, integrated with TiO 2 nanoparticles.

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

Describes acid-base physiology and discusses the diagnosis ... Calculation of the plasma anion gap is particularly useful in identifying the specific cause of metabolic acidosis and in narrowing ...

Deng. More information: Yanan Li et al, MoS 2-confined Rh-Zn atomic pair boosts photo-driven methane carbonylation to acetic acid, Nature Communications (2025). DOI: 10.1038/s41467-024-54061-z ...

HIV invasion through the mucosa of the female lower genital tract contributes the largest number of new HIV infections worldwide. The second leading site of viral invasion is the lower male ...

School of Molecular and Cellular Biology and Astbury Centre, University of Leeds, Leeds LS2 9JT, U.K. School of Molecular and Cellular Biology and Astbury Centre, University of Leeds, Leeds LS2 9JT, U ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Most traditional optical biosensors operate through molecular recognition, where ...

(E) PAE plot for the AlphaFold model in panel D, showing high confidence (low PAE values) for the interaction interface residue pairs. (G) PAE plot for an ... of significant amounts of E1∼Ub conjugate ...