During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

Protease inhibitors are one type of antiretroviral drug used to treat HIV. Their goal is to reduce the amount of HIV virus in the body to levels that are undetectable. That said, protease ...

HIV protease forms proteins at its active site that can lead to the virus. The virus can then replicate itself throughout the body. The POM molecule provides a "second line of attack" against HIV ...

In the PDB, you can find hundreds of structures of HIV protease with anti-HIV drugs. The complex shown here is a mutant form of the protease, which has become resistant to the anti-HIV drugs.

The Trump administration's plan to cut funding for HIV vaccine research comes at a time when the field is making substantial ...

A study by researchers from the University of California, San Francisco has found that patients with HIV infection taking protease inhibitors do not experience short-term adverse virologic effects ...

But unlike the many, more common antiviral drugs that can be used to fight against viruses such as flus, protease inhibitors can also be used to help combat HIV (human immunodeficiency virus).

HIV-1 Protease Inhibitors: Effective Against Malaria?. ScienceDaily . Retrieved May 16, 2025 from www.sciencedaily.com / releases / 2004 / 11 / 041123100855.htm ...

Corticosteroid injections can lead to dysfunctions in cortisol levels in people taking HIV protease inhibitors, according to research published in the online edition of the Journal of Acquired Immune ...

Given that HIV-protease inhibitors (HIV-PIs) are substrates/inhibitors of the multidrug transporter ABCB1, can induce ABCB1 expression, and are used in combination with doxorubicin for AIDS-Kaposi ...

The researchers also found that bone mineral density continued to fall after starting HIV treatment, particularly in individuals who were taking a protease inhibitor. People with HIV are more likely ...

People living with HIV have a significantly increased risk of cardiovascular disease that requires a different level of ...