During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

People living with HIV have a significantly increased risk of cardiovascular disease that requires a different level of ...

Exposure to nucleoside reverse transcriptase inhibitors (NRTIs), which treat HIV and hepatitis B and inhibit inflammasome activation, is associated with a significantly lower incidence of Alzheimer ...

Although it was almost 30 years from when ACE was validated as a target until the first ACE inhibitors appeared on the market, it was only 10 years after the discovery of HIV protease that the ...

Here we have applied a general strategy, inverse design using the substrate envelope, to develop inhibitors of HIV-1 protease. Structure-based computation was used to design inhibitors predicted to ...

The Trump administration's plan to cut funding for HIV vaccine research comes at a time when the field is making substantial ...

These views are her own and not those of her institution. A little over two decades ago, addressing Nigeria’s HIV crisis topped U.S. President George W. Bush’s priorities. Africa’s most ...

Around 1.2 million U.S. adults are living with HIV, but about 13 percent don’t know they have it. Knowing your HIV status can lead to earlier treatment. It can also help prevent HIV from ...

May 29, 2025 — New HIV research shows that small changes in the virus affect how quickly or slowly it replicates and how easily it can reawaken in the body. These insights bring researchers ...

AYA with HIV show increased prevalence of depression (28%), anxiety (22%), PTSD (12%), and sleep disorders (51%). Higher odds of mental health and sleep disorders were observed in AYA with HIV ...

The Trump administration terminated $258 million in funding to the Center for HIV/AIDS Vaccine Development (CHAVD) Friday, including $129 million for Duke. Researchers were told that the ...

ALBANY, Ga. (WALB) - Albany Police (APD) is investigating after a man allegedly engaged in sexual relations without disclosing his HIV-positive status. According to the police report, a woman ...