After the virologic failure of cabotegravir/rilpivirine and despite dual-class resistance mutations, Canadian doctors have ...

(Left) An example of lipodystrophy caused by protease inhibitors. Source: Aesthetic Surgery Journal. (Right) Daily pill burden, then and now. Source: Gilead Biosciences A massive effort By the late ...

HIV protease drugs are already in wide use among HIV patients, who can also be extra susceptible to Candida auris.

Hepatitis C was discovered in 1989. It took 22 years for these two – the first antiviral drugs to cure the infection – to be discovered and developed. (4) Invirase (1995) was the first HIV protease ...

Gilead Sciences Inc. recently disclosed details on the work that led to the discovery of elunonavir (GS-1156), an unboosted HIV protease inhibitor currently in phase I studies.

Between May 1, 2020, and May 31, 2021, they enrolled 169 people with HIV who were been treated with ART with PI, and 338 patients with HIV taking ART without PI.

The first generation of HAART controlled HIV’s protease and reverse transcriptase — essentially tying both of the virus’ hands behind its back. Newer antiretrovirals combine reverse transcriptase ...

Protease inhibitors used to treat HIV-1 infection may also be effective for treatment or prevention of malaria, according to a study published in the December 15 issue of The Journal of Infectious ...

HIV protease inhibitors turn them up and turn them down at the same time. To put that all together and tell a healthcare provider what to do, it turns out, is often quite complex.

Background: HIV-protease inhibitors like Ritonavir produces regressions in HIV-associated Kaposi‘s sarcoma, reportedly due to proteasome inhibition. We have here assessed the effect of Ritonavir and ...