Gru is now firmly a family man: He’s been married to the sunny Lucy Wilde (Kristen Wiig) since Despicable Me 2, and the couple now has a biological son.

In Alzheimer’s disease cohorts with whole genome sequencing and tau and amyloid-β, the authors show that sex, APOE-ε4 and TREM2 impact tau via both Aβ and tau pathways. APOE-ε4 homozygotes ...