Lipid A, the endotoxic component of lipopolysaccharide (LPS), is fundamental to the architecture and function of Gram-negative bacterial outer membranes. It not only anchors LPS to the cell ...

A group of scientists from the National Institute of Technology (NIT) Calicut has developed a new highly sensitive, low-cos ...

Researchers reviewed recent studies showing that gut dysbiosis contributes to heart failure by weakening the gut barrier, ...

A team of scientists from the Calicut-based National Institute of Technology under the Department of Science and Technology (DST) has developed a highly sensitive, low-cost, portable device for ...

Scientists at the National Institute of Technology (NIT) Calicut have developed a breakthrough point-of-care diagnostic device capable of rapidly detecting sepsis, a life-threatening condition caused ...

For 40 years, researchers relied on horseshoe crab blood to catch endotoxins in drugs. Now, synthetic alternatives and ...

In the outer membrane of gram‐negative bacteria, O‐antigen segments of lipopolysaccharide (LPS) form a chemomechanical barrier, whereas lipid A moieties anchor LPS molecules. Upon infection, human ...

TLR4 recognizes LPS LPS is an integral component of the outer membranes of Gram-negative bacteria and can provoke a life-threatening condition called endotoxic shock 15.

The cell wall of Gram-negative bacteria plays a crucial role in the bacteria resistance to certain antimicrobials and its adaptation to the host environment. The first line of cell defense is its ...

A research team from the National Institute of Technology (NIT) Calicut has developed a portable, low-cost device using an electrochemical biosensor to detect sepsis by ...

Gram-negative bacteria, in particular, possess an additional lipid bilayer, the OM, which is impermeable to many antibiotics, thereby limiting treatment options.

Gram-negative bacterial infections are becoming an increasingly serious global health issue U.S. patent applications filed for three novel drug candidates: PKL200, TSL2200, and EAL2200 Continued ...