To understand how DJ-1 hydrolyzes cyclic 3-phosphoglyceric anhydride—a highly reactive, toxic cellular metabolite—researchers ...

A mutant DJ-1 gene causes recessive Parkinson's disease, but the molecular mechanism of this process has not been well ...

Our body is made up of millions of cells that coordinate daily function. They are constantly working to maintain activity and ...

As a result, glucose metabolism is rerouted towards aerobic glycolysis, boosting lactate production. The elevated lactate levels then induce histone lactylation, especially at H3K56, triggering ...

The switch from fetal γ-globin to adult β-globin is controlled by BCL11A. Genetic manipulation of BCL11A improves disease outcomes by turning γ-globin expression back on to compensate for ...

As a result, glucose metabolism is rerouted towards aerobic glycolysis, boosting lactate production. The elevated lactate levels then induce histone lactylation, especially at H3K56, triggering ...