Here, we expand the repertoire of PROTAC compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high ...

Effective mucosal immunity in the intestine involves a fine balance between tolerance of the microbiome, recognition and elimination of pathogens, and inflammatory tissue injury. The anti-inflammatory ...

Archbold softball clinched an outright Northwest Ohio Athletic League title on Monday with a dominant 19-0 run rule road win ...

The Four Seasons” on Netflix might be one of the more confounding examples of Hollywood’s preoccupation with treating any preexisting film or show as intellectual property in need of a ...

Greater Johnstown High School seniors Helen Miller and Dmyah Carr said they were extremely thankful to Johnstown Area ...

This work introduces a magnetic conductive atomic force microscopy (mc-AFM) measurement platform for determining spin polarizations, arising from the chiral-induced spin selectivity (CISS) effect ...

Mike Whaley is returning to his Northeast Kingdom alma mater, this time to promote his latest book. The former Lyndon State ...

Established in 1934, Fisher & Paykel Appliances designs, manufactures & markets a range of innovative household appliances developed with a commitment to technology, design, user friendliness and ...

Inhibition of RJG-2121 probe labeling as calculated using the integrated band intensities from gel-based competitive ABPP studies shown in Figures S2–S6. b Potency values ... and 1% l-glutamine ...

Background: COL4As, a group of six homologous genes that encode the type IV collagen α chains (α1-α6), have been identified as the main components of the collagen network in brain basement membranes.

Three-quarters of the pledge will bolster Thermo Fisher’s manufacturing operations, while the remaining $500 million will expand its R&D efforts. “Thermo Fisher’s commitment to U.S ...

Thermo Fisher's updated 2025 guidance shows a $1 EPS, or 4.2% hit from tariffs and government spending cuts. Thermo can mitigate the tariff issues by next year, as its scale gives it options to ...