Fibrous dysplasia is a rare, mosaic disorder that leads to fractures, pain, and disability. Gain-of-function GNAS variants alter skeletal stem-cell differentiation, which results in the formation ...

A 21-year-old man had received a diagnosis of fibrous dysplasia and the McCune–Albright syndrome at 3 years of age, after a bone fracture. Throughout childhood, he had progressive skull ...

Bone turnover, a process in which old bone is continuously replaced with new bone, is unusually accelerated in fibrous dysplasia and contributes to bone abnormalities.

Malignant fibrous histiocytoma in the bones is a very rare cancer. ... certain chemotherapy treatments, ... You may get a CT scan or MRI to show more details and how much of your bone is affected.

A clinical trial at the National Institutes of Health found that a medication, denosumab, significantly reduced abnormal bone turnover in adults with fibrous dysplasia, a rare disease marked by ...

This article will cover a range of reasons why a person may have shin pain, including symptoms, treatments, ... According to the AAOS, around 7% of all benign bone tumors are fibrous dysplasia.

Pre-existing bone conditions including bone infarcts, chronic osteomyelitis, and fibrous dysplasia may occasionally progress to malignant transformation. Regular monitoring of these conditions ...

SAN FRANCISCO — The presence of fibrous dysplasia alone, without associated visual loss, is not sufficient to warrant prophylactic decompression of the optic nerve, surgeons here advise.

The bone fragment, which comes from the famous archaeological cave site of Krapina, ... "Fibrous dysplasia in a 120,000+ year old Neandertal from Krapina, ...

Adamantinoma of long bones and osteofibrous dysplasia are rare, osteolytic primary bone tumours of uncertain origin containing areas of fibrous and fibro-osseous proliferation. We investigated the ...

Recently, extraordinary progress has been made in our understanding of the mechanisms and molecular pathways underlying focal and sclerotic bone diseases, rare disorders which have a strong ...