A therapeutic antibody’s efficacy is dependent not only on the Fab fragment and its binding activity to the target antigen but also on the Fc fragment and its interaction with key Fc receptors ...

Each of these four IgG subclasses is structurally similar and comprised of a hinge region, Fab region (variable) and Fc region (constant). Figure 2. Four IgG subclasses. Image Credit: ACROBiosystems ...

Understanding these glycosylation patterns is just as important as analyzing other tools like labeled peptides, which are ...

Over the last several decades, antibodies (Abs) have become a valuable weapon in the fight against viral infections, with several studies demonstrating the importance of both neutralizing and ...

CDP860 is an engineered Fab' fragment-polyethylene glycol conjugate, which binds to and blocks the activity of the beta-subunit of the platelet-derived growth factor receptor (PDGFR- β). Studies in ...

Astria Therapeutics to Present STAR-0215 Data at the 2022 Fc Receptor and IgG Targeted Therapies Conference April 21, 2022 08:00 AM Eastern Daylight Time ...

The unique immunoglobulin idiotype (Id) expressed by each B-cell lymphoma is a target for immunotherapy. Vaccination with Id induces humoral and/or cellular anti-Id immune responses. However, the ...

Blood dendritic cell antigen 2 and neonatal fragment crystallizable receptor are two novel strategies in lupus that may play a larger role in the future, according to a presenter at the 2023 AWIR ...

Our cover story this month is on the next wave of immune-based therapies for patients with immune-mediated inflammatory conditions — and the prospects are bright.I want to thank our faculty ...

The Fc gamma receptors play important roles in the initiation and regulation of many immunological and inflammatory processes. They also have the ability to bind RA-associated antibodies.