Spravato (esketamine) is a nasal spray used for depression and was approved by the FDA in 2019. It is specifically for treatment-resistant depression, meaning depression symptoms that have not ...

In “Esketamine for treatment-resistant depression: A trick of smoke and mirrors?” Gastaldon and colleagues note that two of the three short-term studies used for FDA approval did not find ...

Ketamine remains a fairly new player on the field of depression treatment ... You can only receive esketamine nasal spray, IV therapy, and IM injections at a clinic or hospital.

However, Spravato (esketamine) is a patented nasal spray that contains only the S-ketamine molecule. Spravato has been approved by the FDA for adults with treatment-resistant depression since 2019.

Fast-acting antidepressants can work in hours to help you feel better if you have depression or suicidal thoughts. The FDA in 2019 approved the first, a nasal spray called esketamine for treatment ...

17 In patients with treatment-resistant depression, reductions in depressive symptoms and in the risk of relapse were observed with esketamine nasal spray as compared with placebo nasal spray when ...

More information: Jennifer Kern Sliwa et al, Effects of esketamine nasal spray on depressive symptom severity in adults with treatment-resistant depression and associations between the Montgomery ...

More information: Antonio Del Casale et al, Esketamine Combined With SSRI or SNRI for Treatment-Resistant Depression, JAMA Psychiatry (2025). DOI: 10.1001/jamapsychiatry.2025.0200 ...

Esketamine targets the glutamate neurotransmitter pathway, offering a novel mechanism for treatment-resistant depression. The treatment is available through a Risk Evaluation and Mitigation ...

Esketamine combined with a serotonin-norepinephrine reuptake inhibitor (SNRI) for treatment-resistant depression (TRD) was linked to significantly lower rates of several adverse outcomes than ...

The drug is now cleared for use as a standalone treatment for depression. Spravato is made from esketamine, one of two mirror-image molecules found in the anesthetic ketamine. It was approved in ...