A single low dose injection of esketamine given immediately after childbirth reduces major depressive episodes in individuals with depressive symptoms during pregnancy (prenatal depression), finds ...

A single low dose injection of esketamine given immediately after childbirth reduces major depressive episodes in individuals with depressive symptoms during pregnancy (prenatal depression), finds ...

Esketamine-treated participants showed a brief period of increased dissociation compared with the control group. “This to be expected with these drugs,” says Schatzberg.

Meeting Coverage > Psych Congress Esketamine Also Effective Without Adjunctive Antidepressant — Trial data may expand use, with "opportunity to truly individualize treatment" by Kristen Monaco ...

Shuo Wang et al., Efficacy of a single low dose of esketamine after childbirth for mothers with symptoms of prenatal depression: randomised clinical trial, BMJ 2024;385:e078218, DOI: 10.1136/bmj ...

Low-dose esketamine reduced incidence of composite desaturation and hypotension compared with saline (8.2% vs. 21%). Propofol requirements also were reduced with esketamine administration ...

After the first dose, only 29 percent of the esketamine group had "common" or "explicit" suicidal thoughts, compared to 58 percent in the group that had received the placebo.

With every esketamine dose, PCL-5 scores significantly decreased, signaling improvement in PTSD symptoms (B = –0.95; P < .001), according to the abstract.

Spravato, a nasal spray esketamine, was found to work better than Seroquel for treatment-resistant depression, a study in the New England Journal of Medicine finds.

The FDA approved esketamine (Spravato) nasal spray as monotherapy for adults with treatment-resistant depression who had an inadequate response to at least two oral antidepressants, maker Johnson ...