When PC12 cells are deprived of trophic support they undergo apoptosis. We have previously shown that survival of trophic factor-deprived PC12M1 cells can be promoted by activation of the G ...

Together, these studies uncover novel compensatory pathways that may be involved in tumor adaptation to inhibition of the KRAS–RAF–MEK–ERK pathway. Key among these is the activation of ...

Pathway analysis revealed RAS signaling and inflammation were enriched in BRAF V600E compared to WT in both HGG and LGG (NES > 2; FDR < 0.005), regardless of age. When comparing all V600E HGG patients ...

Background: Mitogen-activated protein kinase (MAPK) pathway is a key regulator of cellular proliferation and survival, it is highly correlated with the occurrence of many cancers, JSI-1187 is a potent ...