A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

Aldehydes are capable of modifying DNA and yielding promutagenic lesions, which may, at least partially, account for the observed mutagenic and carcinogenic effects associated with the lipid ...

Objective The obesity epidemic and its metabolic complications continue to be a major global public health threat with limited effective treatments, especially drugs that can be taken orally. Peptides ...

Endogenous and exogenous signals, such as gonadotropins, insulin, and cortisol, are the upstream regulators in follicular lipid metabolic homeostasis, forming a complex and dynamic network in which ...

Depletion of PEBP1 impaired mitochondrial ISR activation by reducing eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and subsequent ISR gene expression, which was independent of ...

Lipid nanoparticles (LNPs) represent a highly promising nonviral delivery platform for a variety of therapeutic nucleic acids, including short interfering RNA (siRNA), mRNA (mRNA), single-guide RNA ...

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1Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California.

Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, United States Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, ...

The authors then zoom in on specific metabolic and epigenetic processes (regulation of S-adenocylmethionine metabolism & histone methylation). Finally, an inhibitor of AurA is used to reduce ...

resulting in diversified pathways that control expression of endogenous and exogenous genes, invasive elements and viruses, and repeated sequences. Deployment of small RNA pathways for ...