With just one month before the start of the regular season, we take a look at every matchup in Week 1 and make our early NFL picks and score predictions.

New Orleans is a 0.5-point favorite in the latest Saints vs. Chargers odds, while the latest NFL odds show the over/under for total points scored at 36.5. The Saints are -112 on the money line, with the Chargers at -108.

Prediction: Expect Indy to build early rhythm with their starters and jump out to a lead. With a projected first-half edge and more aggressive scripts, the Colts look set to cover the first-half spread (Indy –3.5).