View full sizeGru (Steve Carell) and the Minions say goodbye to Dr. Nefario (Russell Brand) in "Despicable Me 2." Universal Pictures "Gru's back in the game!" boasts the animated ex-supervillain ...

Despicable Me 4 has finally hit theaters and fans are asking if Gru’s twin-brother Dru returns in the movie and makes a cameo appearance. Dru was introduced in Despicable Me 3 and was apparently ...

In "Despicable Me 2," Gru tries to raise his children and gets recruited by the Anti-Villain League (AVL). Gru's love interest, AVL agent Lucy Wilde (Kristin Wiig), is introduced, and Dr. Nefario ...

El Macho El Macho is the villain of Despicable Me 2. In the film, he joins forces with Dr. Nefario in order to kidnap and mutate Gru’s minions with the help of the PX-41 formula.

Critics say that, while "Despicable Me 2" doesn't exactly match the quality of its predecessor, the sequel does manage to provide interesting visuals and sight gags for adults and children.

[Warning: The following contains spoilers for Despicable Me 3.] One of the less popular, but always fantastic characters in the Despicable Me franchise is Dr. Nefario, voiced by Russell Brand.