a key regulator of gene transcription needed for generating new neurons, or "neurogenesis." The team's analysis of genetic data suggested that TCF4 is underexpressed in Down syndrome mice but the ...

Gene editing involves precisely cutting DNA, allowing the cell to repair itself. While it has been used to treat genetic conditions like sickle cell anaemia, applying it to Down Syndrome is far ...

Down syndrome (DS) is the most prevalent genetic cause of Alzheimer’s disease (AD). Previous evidence suggests that increased dosage of the amyloid precursor protein (APP) gene plays a crucial role in ...