Nick Safier and his little brother Gabe share the best ritual. When Nick, 28, leaves home and returns, his brother Gabe, 21, who has Down syndrome, gives him a big hug and a kiss on the nose.

About 5,700 babies are born with Down syndrome each year in the U.S., and over 400,000 people in the country currently live with it, according to the Centers for Disease Control and Prevention (CDC).

To mark World Down Syndrome Day on March 21, Fox News contributor Tom Shillue headed to Times Square to speak with a father of a girl with Down syndrome about common misperceptions.